A critical challenge at core facilities are poor quality inputs such as FFPE, liquid biopsies, ancient DNA. These inputs are highly fragmented and degraded and perform poorly on standard NGS workflows. ClaretBio’s mission is to enhance the quality of sequencing data obtained from such challenging sample types. Our flagship library preparation method SRSLY generates high complexity libraries from picogram amounts of fragmented and degraded DNA.  At this webinar, you will hear from two accomplished speakers who have developed robust workflows to challenging samples – non-plasma liquid biopsies and bones to generate high quality NGS data.

In this presentation ClaretBio CSO Dr. Troll discusses features of our enzymatic fragmentation module ForShear, its utility in NGS library preparation of FFPE DNA and important considerations during experimental set-up

In this video, Dr. Katie Miller at Nationwide Children’s Hospital talks about their work on brain mosaicism and focal epilepsy in pediatric cases. She also highlight the various next-generation sequencing methods including SRSLY that were use in this study.

In this talk by Brent Lehman, learn about how SRSLY enables NGS analyses of samples recovered through the Missing in Action Recovery and Identification Project.

In this talk by Dr. Lydia Freddolino, learn about how NGS tools such as SRSLY can be used for genome-wide profiling of RNA-DNA hybrids in bacteria for better understanding of R-Loops a structural that places a central role in bacterial genomic evolution.

Recovering human mitogenome profiles from DNA derived from chemically treated U.S. Military unknown samples. Watch how lessons learnt from ancient DNA genomic technologies can be used to resolve Forensic genomic questions.

Watch this webinar to learn about a novel fragment type in plasma - Ultra Short single-stranded cell-free DNA (uscfDNA) and how SRSLY can help capture sequencing information from these fragments that are lost in traditional NGS methods

Watch this joint webinar hosted by Horizon Discovery which showcased the utility of Horizon Discovery cfDNA standards in ClaretBio's SRSLY pipeline.

The first talk presented by ClaretBio discusses the application of SRSLY in hybrid capture pipelines. The 2nd presentation by Horizon Discovery showcases the suite of NGS standards available at Horizon Discovery.

In this webinar Ms. Adrienne Chang talks about the challenges in metagenomic cfDNA sequencing assays and the utility of SRSLY and other single-stranded library preps in retention of short fragments.

Our CEO Dr. Kelly Harkins presented at the Genomics Social Hour conducted by the California Academy of Sciences. She spoke about the application of SRSLY in generating libraries from highly degraded DNA such as aDNA.

This video provides an overview of the SRSLY technology and it’s application with a variety of input types